Center for Computational Genomics - CWRU

Center for Computational Genomics - CWRU - ABOUT

The Center for Computational Genomics is an interdisciplinary research center, established for enhancing CWRU research and training effort towards understanding the human genome.

The participating departments of the center are:

Electrical Engineering & Computer Science

Biomedical Engineering

Epidemiology & Biostatistics

Biology

Genetics

Statistics

The center brings together faculty, postdocs and graduate students from diverse backgrounds such as computer science, genetics and genetic epidemiology, with the common goal of design, implementation, testing and practical evaluation of algorithmic, heuristic and database tools that enhance genomic analysis methods.

The current activities of the center include:

Algorithmic analysis of gene transcription and replication

Comparative genomics and synteny, gene expression profiles

These problems require mathematically sophisticated and computing intensive techniques that combine combinatorial, probabilistic/statistical and machine learning approaches

We encourage students interested in this new and exciting field to apply for our graduate programs in computer science, genetics, genetic epidemiology and systems biology.

Systems Biology at CWRU since 1968

Systems Biology research and education was launched at the Case Institute of Technology in 1968 at the International Symposium "Systems Theory and Biology" with participation from leading biology and systems sciences researchers.

The proceedings were published by J. Wiley and Sons and received world-wide attention with reviews in English, German, French, Spanish, Rumanian and other journals.

A review in Science, "A Means Towards a New Holistic" (Vol. 161, No. 3836, July 1968) concludes with the statement, "A field of systems biology with its own identity and its own right" has been launched.

Systems Biology research at the Systems Research Center was formed in 1969 with Mike Mesarovic, Robert Plonsey and David Fleming, which in 1973 grew into the Bio-Medical Engineering Department. That was problably the first Biomedical Department jointly in the Medical School and School of Engineering.

In the IEEE Control Systems Magazine review article in August 2003, "System Biology: Looking at opportunities and challenges in applying systems theory to molecular and cell biology", Olaf Wolkenhauer, et. al. state, "Systems Biology has a history and its early stages in the 1960s involved eminent researchers, including Wiener, Kalman, Bertalanffy, Rosen and Mesarovic."